Introduction of Drug Affinity Responsive Target Stability (DARTS) Drug target protein identification is an important step in the research and development of new drugs. Drug Affinity Response Target Stability (DARTS) is a technique that can rapidly and directly identify potential target proteins of small molecule drugs. That is, it prevents the target protein from being hydrolyzed by…
What is CAR T-cell therapy? Car-t cell therapy involves genetically engineering T cells isolated from patients or allogeneic donors to express chimeric antigen receptors (CAR) that specifically recognize and kill tumor cells. As a “living” drug, CAR-T therapy is very different from traditional drugs. It is a new type of precision targeted therapy for…
Most biological agents enter the body directly without passing through the gastrointestinal tract, so in addition to biological activity, relevant authorities have very strict requirements on impurities in drugs. Among them, the host cells residual DNA has always been the focus of regulatory agencies because of its special potential safety risks. Although recombinant protein drugs, antibody…
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Fc fusion protein (Fc-Fusion) has a complex and diverse molecular structure, and may contain glycosylation modification sites at amino acid 297 of its Fc fragment and the Fab region of some molecules. Moreover, its biological ligands are structurally diverse, and their glycosylation modifications may also be complex, usually involving multiple N-glycan and O-glycan sites and a large number of…
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Risk analysis is used for the evaluation of potential risk problems that could be encountered in connection with the use of a medical device. Biological hazards, risk characterization, and toxicological risk assessment are required to ensure the safety of a novel medical device and meet the requirements of marketplaces. Standard for Risk Assessments Risk assessments…
Irritation represents local tissue inflammation response to chemicals, without a systemic immunological component, and irritation is characterized by inflammation, redness, swelling, heat, or pain. Irritation testing is used to assess the potential of a medical device to cause an immediate irritation reaction in the skin, mucosal, or ocular tissues following a single or repeated exposure…
By peeling back the layers, understanding its causes, and exploring treatment options, dermatologists empower individuals to embrace their skin’s unique stories.
IPTV (Internet Protocol Television) în România este un serviciu care permite utilizatorilor să vizioneze conținutul televizionat prin intermediul internetului, în locul metodelor tradiționale precum antena satelit sau cablu. Această tehnologie oferă o gamă largă de canale TV, inclusiv canale locale, naționale și internaționale, și permite accesul la diverse programe, cum ar fi filme, seriale, emisiuni…
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Extracellular vesicles are a series of membrane-structured vesicles released by cells, including exosomes, microvesicles, and apoptotic bodies. Extracellular vesicles are composed of various lipids and membrane proteins, some of which special membrane proteins help target specific tissues and cells, while others ensure that non-specific interactions are minimized, these physiological properties endow Thanks to their excellent biocompatibility…
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Gold is a chemically stable metal with a molar mass of 196.96657 g/m and a density of 19.3 g/cm3. It is often used for decoration and money, but its properties change strangely when its size shrinks to the nanometer level. Gold nanoparticles have special physical and chemical properties different from bulk gold because of their…
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